Description
Chromium Polynicotinate is an essential micromineral that is thought to be the active component of glucose tolerance factor (GTF), which is a complex of molecules found in the body. GTF enhances the blood sugar-lowering effects of insulin, which facilitates the uptake of glucose into cells. Chromium is used for the treatment of obesity and metabolic syndrome because of its effect on lipids and body composition. Chromium Polynicotinate is often refered to as niacin-bound chromium because it includes chromium bound to molecules of niacin. The nicotinate salt increases absorption, retention and accumulation of chromium compared to other inorganic salts. Pharmacokinetics: Approximately 0.5-2% of chromium is absorbed. Absorption seems to occur primarily in the jejunum. Absorption of chromium may be affected by interactions with other metals, including zinc, iron, vanadium, oxalate, and phytate. After absorption, trivalent chromium is bound to transferrin. The distribution may occur across fast, medium, and slow compartments, with serum chromium not in equilibrium with tissue-organ stores.
Pregnancy and breast-feeding women should not take
Chromium Polynicotinate is an essential Micromineral.
PRODUCT INFORMATION FOR CHROMIUM POLYNICOTINATE
PROPRIETARY NAME (and dosage form):
Chromium Polynicotinate (tablets) COMPOSITION: Each tablet contains the following as active ingredients: Chromium polynicotinate 200mg
Inactive ingredients: micro crystalline cellulose, vinylpyrrolidone-vinyl acetate, colloidal silicon dioxide, magnesium stearate.
PHARMACOLOGICAL ACTION:
Chromium is thought to be the active component of glucose tolerence factor (GTF) which is a complex of molecules found in the body. GTF enhances the blood sugar-lowering effects of insulin, which facilitates the uptake of glucose into cells. It is suspected to potentiate insulin by increasing receptor numbers and affinity, and increasing insulin binding to cells. This suggests that chromium potentiates the effect of insulin in patients with diabetes which translates into decreased insulin resistance, improved glucose tolerance, and lower blood glucose levels. Chromium is used for the treatment of obesity and metabolic syndrome because of it effect on lipids and body composition. Chromium polynicotinate is often refered to as niacin bound chromium because it includes chromium bound to molecules of niacin. The nicotinate salt increases absorption, retention and accumulation of chromium compared to other inorganic salts. Pharmacokinetics: Approximately 0.5-2% of chromium is absorbed. Absorption seems to occur primarily in the jejunum. Absorption of chromium may be affected by interactions with other metals, including zinc, iron, vanadium, oxalate, and phytate. After absorption, trivalent chromium is bound to transferrin. The distribution may occur across fast, medium, and slow compartments, with serum chromium not in equilibrium with tissue-organ stores.
INDICATIONS:
Chromium polynicotinate can be used to aid the following: - Obesity - Diabetes mellitus - Insulin resistance - Post-Meal fatigue - Reduce carbohydrate craving - Polycystic ovarian syndrome - Increase energy and vigour
CONTRA-INDICATIONS:
There are no known contra-indications.
WARNINGS:
Dose exceeding the recommended dosage can cause anaemia and liver dysfunction. Do not exceed recommended dosages unless on the advice of a healthcare provider. Do not use this product if you are allergic to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy.
INTERACTIONS:
Chromium polynicotinate should be used with caution if using the following medicines: - Insulin - Levothyroxine - Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Drugs that deplete chromium levels or affect absorption include: - Antacids - Corticosteroids - H2-Blockers - Proton Pump Inhibitors (PPIs)
PREGNANCY AND BREAST-FEEDING:
Pregnancy and breast-feeding women should not take more than 1 tablet per day, unless under the supervision of a medical practitioner.
DOSAGE AND DIRECTIONS FOR USE:
Adults and children over 12 years of age: Take 1 tablet twice daily with meals, or as recommended by your healthcare provider. This dose can be doubled after 1-2 months if required. Children 7-12 years of age: Take 1 tablet daily with a meal, or as recommended by your healthcare provider.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Side effects:
Chromium polynicotinate is generally well tolerated and with no side effects reported at the recommended doses and is considered one of the least toxic nutrients. Side effects at higher doses that have been reported include transient gastrointestinal irritation, headaches, insomnia, sleep disturbances, irritability, and mood changes .
Special Precautions:
Use cautiously in individuals with renal or hepatic insufficiency. Use cautiously in individuals with diabetes or in individuals receiving oral hypoglycemics or insulin. Blood glucose should be closely monitored and the dosage of diabetic agents may need to be reduced. This should be carefully coordinated under the supervision of a healthcare provider.
KNOWN SYMPTOMS OF OVERDOSAGE AND P
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