The main difference between the Adjustable LED Digital Microscope with 1080p HD Camera for R599 and the USB Digital Microscope for R350 is the camera resolution. The R599 microscope has a 1080p HD camera that will provide much clearer and sharper views than the R350 microscope, allowing you to see finer detail. While the R350 microscope is more affordable, the upgraded camera on the R599 model is worth paying a bit more for if higher image quality is important to you. Both would let you explore the microworld, but the 1080p resolution of the R599 model will give you a more satisfying microscopic experience.